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Ointment Gepatrombin G


Pharmachologic effect

Combined drug with antithrombotic, anti-inflammatory and venosclerosis effect for topical application in proctology.

Heparin is an anticoagulant of direct action. With external application has a local antithrombotic, antiexudative and moderate anti-inflammatory effect; promotes the regeneration of connective tissue; prevents coagulation of blood in the hemorrhoids.

Prednisolone - GCS, has anti-inflammatory, antiexudative and antiallergic effect, reduces itching, burning sensation, pain in the anorectal area.

Lauromacrogol 400 (polidocanol) has a local anesthetic effect and provides sclerosis of hemorrhoids.


Absorption and Metabolism

After absorption, biotransformed in the liver (partly by the enzyme hepatic heparinase) and in the reticuloendothelial system.

Distribution and deduction

Binding to plasma proteins is 95%.

Vd increases with increasing dose. It is excreted by the kidneys. T1 / 2 - 60-90 min.


Absorption and Metabolism

Prednisolone after absorption is biotransformed in the liver.


About 1% is excreted in the urine unchanged. Biological T1 / 2 is 18-36 h, and T1 / 2 from the plasma is 115-212 min.

Indications for use of the drug
- external and internal hemorrhoids;

- thrombophlebitis of the veins of the anus;

- fistulas, eczema and itching in the anus;

- cracks of the anus.

Dosing regimen
Ointment is applied to the affected areas with a thin layer 2-4 times / day; after the disappearance of painful sensations - 1 time / day for 7 days.

Rectal suppositories are administered 1-2 times / day after defecation.

To insert the ointment into the rectum, a screw-on tip is used, which is injected into the rectum and a small amount of ointment is squeezed out by lightly pressing the tube.

Side effect
Local reactions: allergic reactions, skin hyperemia.

With long-term use and / or when applied to large surfaces, systemic side effects are possible.

Contraindications to the use of the drug
- bacterial, viral, fungal skin lesions;

- tuberculosis;

- syphilis;

- skin tumors;

- reactions to vaccination;

- predisposition to bleeding;

- I trimester of pregnancy;

- Hypersensitivity to the components of the drug.

Application of the drug during pregnancy and lactation
The drug is contraindicated in the first trimester of pregnancy.

special instructions
When applying a large amount of the drug on the damaged skin or mucous membranes, the regeneration processes slow down.

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