Acyclovir 5% Cream
Acyclovir of external use - herpes skin and mucous membranes, genital herpes
Dosing and Administration Aciclovir:
Outwardly. The cream is applied to the affected areas 4-6 times a day (as soon as possible after the onset of infection). It is important to begin treatment of a recurring infection during the prodromal phase or at the very onset of infection. Duration of treatment - at least 5 days, a maximum of 10 days.
Locally. Eye ointment is squeezed out by a tape 1 cm long and placed in the lower conjunctival sac 5 times a day (every 4 hours). Treatment is continued for at least 3 days after healing.
Pharmachologic effect Aciclovir:
Antiviral drug. High selectivity of action and low toxicity for humans "embedded" in the DNA synthesized by the virus, blocks the multiplication of the virus. The specificity and very high selectivity of the action are also due to its predominant accumulation in cells infected with the herpes virus. Highly active against Herpes simplex virus type 1 and type 2; a virus that causes varicella and herpes zoster (Varicella zoster); of the Epstein-Barr virus (the types of viruses are listed in ascending order of the MIC value). Moderately active against CMV.
With herpes, prevents the formation of new elements of the rash, reduces the likelihood of cutaneous dissemination and visceral complications, accelerates the formation of crusts, reduces pain in the acute phase of herpes zoster. It has an immunostimulating effect.
With external application - soreness, burning, itching, skin rash, vulvitis.
When applying ophthalmic ointment - burning in the place of application, blepharitis, conjunctivitis, superficial keratopathy.
Symptoms: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, impaired renal function, lethargy, convulsions, coma.
Treatment of overdose: maintenance of vital functions, hemodialysis.
Cream for dermal application should not be applied to the mucous membranes of the mouth, nose, eyes and vagina.
Aciclovir ointment is effective for the prevention of herpes simplex recurrences.
The effectiveness of treatment will be higher the earlier it was started (at the first signs of infection).
To realize the therapeutic effect, the state of the body's immune system is important. Patients with reduced immunity (with bone marrow transplantation) on the background of topical application of the ointment of the drug should be given a systemic administration of the drug, as well as in the case of severe and recurrent course of herpetic infection.
A strip of ointment 1.25 cm should be applied on 25 square cm of affected skin. To prevent autoinoculation on other skin areas, it is necessary to use fingertips or rubber gloves.
This drug does not prevent sexual transmission of herpes, therefore during treatment it is necessary to abstain from sexual intercourse, even in the absence of clinical manifestations.